The residential school at Condover Hall in Staffordshire will cater for 110 young people aged four to 19.
It will be run by Priory Education Services, which already operates 14 specialist residential schools and colleges for young people with social, emotional and behavioural difficulties and autistic spectrum disorders.
The majority of places at the schools are publicly funded.
A spokeswoman for Priory Education Services said the new school would be its first to cater for children with autism and Asperger syndrome.
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