The obesity and fitness levels, cardiovascular risk factors, diet and psychological wellbeing of 400 12- and 13-year-olds at Porth County Community School will be monitored over an 18-week period by researchers from the University of Glamorgan.
The pupils will take part in specially-designed exercise sessions, and their activity and eating habits will be examined both inside and outside of school hours.
The aim is to find out how best to improve the health of young people, what barriers there are to a healthy lifestyle and how to tackle the obesity epidemic.
Professor Julien Baker, who will be leading the research team, claimed the study was the first of its kind.
He said: "We will be exploring the effects of diverse exercise interventions on the health of the young people as well as their perceptions of a healthy lifestyle, and perceived barriers to healthy living in this population.
"The study's findings will help guide future intervention studies for improving young people's health, and inform and shape future health and education policy in Wales."
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