Speaking at a Westminster Education Forum seminar on child protection, she told delegates that protecting children is "probably the most difficult job of all".
"What happened to Peter Connelly was absolutely devastating," she said. "I can tell you that there was never any question about me not feeling sorry or distressed about what happened to that little boy."
She claimed the media allegations, which suggested that she was not remorseful about his death, were "a very callous twist in the story". "I was abused across the world," she said.
She called on government to overhaul public accountability so that in future agencies share proper responsibility for mistakes.
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