She will relinquish her role as children's minister at the next reshuffle, expected on Friday after this week's European and local elections.
In a letter to Prime Minister Gordon Brown, Beverley Hughes said: "I would not have chosen the current appalling climate to announce my decision when so many Members are resigning for reasons to do with their Parliamentary allowances. I want to make it absolutely clear that this has nothing whatsoever to do with my decision or the reason for making it public now."
The letter added: "There are a number of personal and family issues which, taken together, are such that I cannot make the commitment to be in Parliament and away from home for a further five years beyond the next General Election. I now want to be at home much more than being a Minister or MP will ever allow."
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