The National Care Homes Association, which counts children's homes and homes for people with learning disabilities among its members, said at least 500 care homes had closed since the introduction of the Care Standards Act 2000.
Last week more than 500 people attended a rally at Westminster organised by the association.
Its chief executive, Sheila Scott, said the introduction of the commission on 1 April represented an opportunity to review the effects of the standards.
She claimed care homes were struggling to deal with the sheer volume of red tape.
Her views were backed up by a leading independent children's home provider.
Janet Rich, a trustee of the Bryn Melyn Group Foundation, said: "The care homes sector was caught completely unawares by the introduction of the Care Standards Act."
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