The donation made by the Paul Hamlyn Foundation (PHF) will be used to fund an endowment, enabling the charity to scale up its work on delivering children's rights.
The newly-created Hamlyn Endowment for the Rights and Voice of Children will also help the charity increase its capacity to provide legal advice for children and families who struggle for representation.
Coram has been supported by PHF for more than two decades after it awarded its first grant to the charity in 1997.
Dr Carol Homden, Coram's chief executive officer, said the landmark gift from PHF was a reflection of its commitment to marginalised children and young people.
"We are creating the space to bring together people from all walks of life to champion a better world where all children have the chance and the resources they need to live a fulfilling life," said Homden.
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