Speaking to The Times he said the change could be dangerous and was driven by a recent push to reduce the number of quangos, rather than the best interests of children.
"I would rather resign now and highlight what I believe is a mistake for child protection than find myself resigning in two or three years' time because something had gone horribly wrong and we'd made serious errors," Gamble told The Times.
"It's become less important to save kids than to save face.
"Ceop works because it is about child protection first and foremost, but I'm afraid it is being dragged back into the blue serge of policing."
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